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. 2010 Mar 19;6(3):e1000884. doi: 10.1371/journal.pgen.1000884

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Pretorius et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Schematic for the targeted alteration of the splice donor and acceptor sites of exon 8 (asterisk) found in the Bbs3L transcript. Homologous recombination leads to the inclusion of these altered sites and the loss of Bbs3L. Hematoxylin/eosin staining of cryosections from 8-month old Bbs3L^+/+ (B,C) and Bbs3L^−/− (E,F) mouse retinas. Disruption of the normal photoreceptor architecture was observed in Bbs3L^−/− mice. Immunohistochemistry analysis of cryosections from (D) wild-type and (G) targeted mutants retinas using the Bbs3 antibody (green) and rhodopsin (red), a marker for rod photoreceptor outer segments. To-Pro3 was used as a counterstain for nuclei. PR, photoreceptor; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer.