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. 2010 Mar 19;6(3):e1000821. doi: 10.1371/journal.ppat.1000821

Figure 2. Location of MAb epitopes and informative sites on DENV3 E protein.

Figure 2

The figure is based on the structure of the ectodomain of DENV3 E protein solved by Modis and colleagues. A. The flavivirus E protein consist of three beta-barrel domains designated domains I (red), II (yellow) and III (blue). The native protein is a homodimer that lies flat on the surface of the virus. The top image depicts the major antigenic sites on domains I and II (see Table 1 for details). The bottom image displays the location of informative sites on domains I and II (pink). B. An enlarged view of domain III displaying antigenic sites and informative sites. The left image displays the lateral ridge and A strand epitopes. The right image displays the domain III informative sites (pink).