Table 1. Location of antigenic sites and informative sites on dengue type 3 E protein.

Domain of DENV3 E protein1	Antigenic region2	Flavivirus E protein mutations that influence mouse Mab binding3	DENV3 E protein informative sites within antigenic region4
EDI (AA 1–52,132–191,278–294)	Lateral Ridge	166–169, 179, 291	160, 169, 171, 172
	EDI-EDII interphase	49–52, 136, 184–187,268–277	132, 139, 270
EDII (AA 53–131, 192–278)	Central Region	123–128, 210, 215, 232–233	62, 62, 120, 124,224, 226, 231
	Lateral Ridge	67–72, 75–76, 81–83, 86, 112	68, 81
	Fusion Loop	99–107
EDIII (AA 295–392)	Lateral Ridge	301–303, 327–330, 381–382	301–303, 329, 355, 380, 383
	A strand	305–308

¹The amino acids that form each domain of DENV3 E protein are according to Modis et al [12].

²The antigenic regions are based on the assignments and nomenclature used by Pierson et al [19].

³Based on Roehrig and Pierson [10],[19].The numbering is based on the DENV3 E protein sequence.

⁴DENV3 E protein informative sites were identified as described in Figure 1.