Table 2. Frequency of rescue of cleft palate by muscimol in Gad1-/- and Viaat-/- mice.
| Frequency of Cleft Palate | |||
| Genotype | PBSa | Muscimol (Viaat) | Muscimol (Gad1) |
| +/+ | 0/19 | 1/21 | 1/10 |
| +/− | 1/46 | 0/34 | 1/31 |
| −/− | 19/19 | 16/20 | 7/14 |
The frequency of cleft palate is expressed as the number of E17.5 day mice exhibiting a cleft palate over the total number examined for that injection condition.
The frequency of cleft palate in Gad1-/- E17.5 mice is 100%. In the case of the Viaat mutant mice we have examined over 200 newborn or late gestation embryos and the cleft palate phenotype is present in 100% of the offspring.
a
PBS injected controls were Viaat +/− dams from ViaatlacZ heterozygote intercrosses.