Skip to main content
. 2010 Mar 19;5(3):e9771. doi: 10.1371/journal.pone.0009771

Figure 5. Footprint of modified HA 1.7 TCR on HLA-DRβ1*04 molecules.

Figure 5

(A,B) Footprint of the HA 1.7 TCR molecule modified according to the Vβ12 clone 3 sequence of protected Aotus 191, in HLA-DRβ1*0403 molecule. (D,E) Footprint of the HA 1.7 TCR molecule modified according to Vβ15 clone 5 sequence of the non-antibody producer, non-protected Aotus monkeys 148 on the HLA-DRβ1*0422 molecule. (B,E) Frontal views of the same complexes and view rotated 90°. (C,F) H bonds established between HLA-DRβ1*0403 and HLA-DRβ1*0422 with HA1.7 TCR-like modified molecules with their corresponding interatomic distances indicated in Amstrongs (Å). Salt bridges are highlighted in dark gray while interactions involving different atoms are highlighted in pale gray, and interactions involving the same residues in both complexes are not highlighted.