Table 3.
VEGF-C/VEGFR3, VEGF-D/VEGFR2, and VEGF-D/VEGFR3 ratios and association with clinico-pathological features in mismatch repair-proficient colorectal cancer.
| VEGF-C/VEGFR3 | VEGF-D/VEGFR2 | VEGF-D/VEGFR3 | |||||
|---|---|---|---|---|---|---|---|
| P-value | P-value | P-value | |||||
| TNM stage | I+II | 6.0 ± 21.0; 0.95 |
0.265 | 1.8 ± 9.1; 1.0 |
0.55 | 6.6 ± 22.4; 1.03 |
0.981 |
| III | 3.99 ± 13.4; 0.79 |
0.94 ± 0.1; 1.0 |
13.2 ± 32.0; 1.05 |
||||
| IV | 5.93 ± 19.7; 1.0 |
4.67 ± 18.8; 1.0 |
7.14 ± 23.3; 1.05 |
||||
| Tumour grade | G1-2 | 5.28 ± 18.3; 0.95 |
0.116 | 2.46 ± 11.9; 1.0 |
0.274 | 8.34 ± 25.4; 1.05 |
0.317 |
| G3 | 4.94 ± 18.1; 0.75 |
0.96 ± 0.17; 1.0 |
11.9 ± 30.5; 1.0 |
||||
| Vascular invasion | Absent | 4.56 ± 16.8; 0.95 |
0.928 | 2.2 ± 10.5; 1.0 |
0.53 | 8.75 ± 26.2; 1.0 |
0.158 |
| Present | 6.74 ± 21.4; 0.95 |
2.34 ± 11.6; 1.0 |
9.7 ± 27.1; 1.05 |
||||
| Tumour border configuration | PM | 3.9 ± 15.7; 0.95 |
0.349 | 1.82 ± 9.04; 1.0 |
0.172 | 7.62 ± 24.5; 1.0 |
0.437 |
| IM | 6.67 ± 20.7; 0.95 |
2.53 ± 12.3; 1.0 |
10.5 ± 28.3; 1.05 |
||||
| PTL infiltration | Absent | 6.15 ± 20.1; 0.95 |
0.733 | 1.96 ± 9.9; 1.0 |
0.538 | 10.6 ± 28.9; 1.0 |
0.575 |
| Present | 1.09 ± 1.5; 0.85 |
3.18 ± 14.4; 1.0 |
1.79 ± 3.0; 1.05 |
||||
Mean ± SD, median values. Kruskal-Wallis or Wilcoxon Rank Sum Test. PM = pushing/expanding margin; IM = infiltrating margin; PTL = peritumoral lymphocytic.