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. Author manuscript; available in PMC: 2010 Sep 18.
Published in final edited form as: Nature. 2010 Feb 21;464(7287):436–440. doi: 10.1038/nature08803

Figure 1. Mad2 Overexpression Cooperates with KrasG12D in Lung Tumorigenesis.

Figure 1

a, Mad2 western blot of TI-KM lungs maintained with (+) or without (−) doxycycline. b, Lung weights from TI-K and TI-KM mice on doxycycline for 8 weeks (Right). Representative macroscopic pictures show lung tumor-size (dotted lines). c, Total tumor area in TI-K and TI-KM lungs. d, H&E from TI-K or TI-KM mice after 8 weeks on doxycycline (left panel), Ki67 staining (middle panel) and TUNEL (right panel) (black bar: 100 μm). e, Tumor nodule/mm2 of lung tissue in TI-K versus TI-KM animals. f, Percentage of Ki67 positive cells. g, Kaplan-Meier curve of TI-K and TI-KM mice. Error bars represent mean and s.e.m. from at least 4 different mice. P values were determined by unpaired t test.