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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Ann Surg Oncol. 2009 Dec 22;17(4):1094–1100. doi: 10.1245/s10434-009-0868-8

Figure 1. NIR Fluorescent Contrast Agent and Imaging System.

Figure 1

A. Methylene blue (MB) chemical structure and molecular weight (MW).

B. Absorbance (solid curve; left axis) and fluorescence emission (dotted curve; λExc = 655 nm; right axis) spectra of 10 μM MB in 100% serum at 37°C.

C. Schematic of the FLARE™ (Fluorescence-Assisted Resection and Exploration) intraoperative NIR fluorescence imaging system, showing excitation and emission wavelengths, and dichroic mirrors D1 and D2. Camera images are acquired and displayed simultaneously, and in real-time.