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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Ann Surg Oncol. 2009 Dec 22;17(4):1094–1100. doi: 10.1245/s10434-009-0868-8

Figure 5. Histological Analysis of Normal and Tumor-Bearing Pancreas.

Figure 5

A. Consecutive sections from normal rat pancreas stained with H&E (left) or unstained and imaged at 700 nm using a NIR fluorescent microscope (right). Rats were either uninjected (top row) or injected IV with 1.5 mg/kg MB and sacrificed at 15 min post-injection (bottom row). NIR fluorescence images have identical exposure times (5 sec) and normalizations. Results are representative of n = 3 independent experiments. I = pancreatic islets; E = exocrine pancreas.

B. Consecutive sections from insulinoma-bearing pancreas of NOD/ShiLt-Tg(RipTAg)1Lt/J mice stained with H&E (left) or unstained and imaged at 700 nm using an NIR fluorescent microscope (right). Mice were either uninjected (top row) or injected IV with 1.5 mg/kg MB and sacrificed at 15 min post-injection (bottom row). NIR fluorescence images have identical exposure times (5 sec) and normalizations. Results are representative of n = 3 independent experiments. Insulinoma is indicated; E = exocrine pancreas.