. 2010 Mar;71(2):278–289. doi: 10.15288/jsad.2010.71.278

Table 3.

Baseline regional metabolite concentrations

					Effect size (Cohen's d)
Region	Metabolite	nsLD (n = 26) M (SD)	Abstainers (n = 18) M (SD)	Resumers (n = 33) M (SD)	Resumers vs. nsLD	Resumers vs. abstainers
DLPFC	NAA	34.0 (3.5)^a	35.6 (4.3)^b	31.1 (3.8)^a,^b	0.87	1.10
	Cr	22.3 (2.3)	35.6 (4.3)^b	21.6 (2.6)^b		0.90
	Cho	5.3 (0.8)	5.7 (0.8)	5.1 (0.7)
	mI	17.6 (3.2)	19.3 (4.5)	18.6 (3.3)
ACC	NAA	31.2 (4.1)^a	31.8 (3.5)^b	29.1 (4.1)^a,^b	0.52	0.71
	Cr	20.2 (3.1)	21.7 (2.7)	20.1 (3.2)
	Cho	6.5 (0.9)	6.6 (0.9)	6.0 (1.3)
	mI	18.2 (2.6)	19.9 (3.7)	18.4 (4.2)
Insula	NAA	33.0 (3.2)^a	32.7 (3.4)^b	31.1 (2.8)^a,^b	0.63	0.52
	Cr	23.0 (2.6)	23.3 (3.1)	23.2 (2.9)
	Cho	6.5 (0.8)	6.1 (1.1)	6.4 (0.9)
	mI	19.1 (3.3)	20.2 (4.8)	20.4 (3.2)
Vermis	NAA	33.5 (3.3)^a	35.6 (4.3)^b	31.4 (3.7)^a,^b	0.60	1.10
	Cr	32.7 (3.4)	34.7 (5.6)^b	31.7 (4.6)^b		0.65
	Cho	8.5 (1.1)	8.2 (1.7)	8.0 (1.4)
	mI	24.1 (3.9)	26.2 (9.6)	23.8 (5.1)
SCR	NAA	31.8 (3.4)^a	31.5 (2.8)^b	29.4 (3.0)^a,^b	0.75	0.72
	Cr	18.6 (2.0)	19.6 (2.0)^b	18.1 (2.2)^a,^b		0.71
	Cho	5.9 (0.8)^a	5.8 (0.7)^b	5.3 (0.7)^a,^b	0.83	0.74
	mI	16.9 (2.3)	18.1 (3.1)	17.2 (2.8)

Notes: nsLD = light-drinking nonsmoking controls; DLPFC = dorsolateral prefrontal cortex; NAA = N-acetylaspartate; Cr = creatine-containing metabolites; Cho = choline-containing metabolites; mI = myoinositol; ACC = anterior cingulate cortex;

resumer < nsLD, p < .05;

resumer < abstainer, p < .05.