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. 2010 Mar;162(3):647–654. doi: 10.1111/j.1365-2133.2009.09436.x

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Journal compilation © 2010 British Association of Dermatologists

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Fig 2 — Improvement in the appearance of periorbital wrinkles for the full study population and 24-week cohort. Changes were determined by expert visual comparison of subject images before and after treatment, using a ± eight-point scale. Error bars represent SEM. Entire population at 8 weeks: n=90 in the tretinoin regimen group; n=95 in the niacinamide/peptide/retinyl propionate (NPP) regimen group. Cohort at 8 weeks: n=25 in each group. Cohort at 24 weeks: n=25 in the tretinoin regimen group; n=23 in the NPP regimen group.