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Table 4.

Changes in stratum corneum protein analytes

	Percentage change from baseline week 8 (entire population)			Percentage change from baseline week 8 (cohorts)			Percentage change from baseline week 24 (cohorts)
	Tretinoin regimen	NPP regimen	P-value	Tretinoin regimen	NPP regimen	P-value	Tretinoin regimen	NPP regimen	P-value
Soluble protein (μg mL⁻¹)	140·44^*	−9·43	< 0·01	160·62^*	−1·83^*	< 0·01	72·98^*	−43·64^*	< 0·01
HSA (ng mL⁻¹)	52·41^*	−33·01^*	< 0·01	62·55^*	−39·74^*	< 0·01	−9·43	−73·39^*	< 0·01
Involucrin (ng μg⁻¹ soluble protein)	115·28^*	0·46	< 0·01	155·27^*	4·95	< 0·01	51·71	−31·61	< 0·05
Keratins 1, 10 and 11 (ng μg⁻¹ soluble protein)	−58·79^*	27·06^*	< 0·01	−62·07^*	18·30	< 0·01	−7·74	179·90^*	< 0·01

HSA, human serum albumin; NPP, niacinamide/peptide/retinyl propionate.

Significantly different from baseline at P<0·05. Listed P-values are for treatment comparisons.