Table 1.

List of mutations tested in this study

Chromosomal alleles
Strain no.	Gene	Human allele	S. cerevisiae allele	Source
Mutations
RDKY7071	MLH1	R217C	R214C	a
RDKY7091	MLH1	R265H	R265H	a
RDKY7092	MLH1	V326A	I326A	a
RDKY7093	MLH1	K84E	K81E	a
RDKY7094	MLH1	V716M	L731M	a
RDKY7095	MLH1	T117M	T114M	a
RDKY7100	MSH2	C333R	C345R	a
RDKY7101	MSH2	D506Y	D524Y	a
RDKY7102	MSH2	E198G	E194G	a; 4, 33
RDKY7103	MSH2	I194T	L190T	b
RDKY7104	MSH2	E701K	E720K	b
RDKY7107	MSH6	S144I	S107I	a
RDKY4493	MSH6	V509A	V410A	a
RDKY7110	PMS1	E705K	E738K	a
Polymorphisms
RDKY7096	MLH1	D132H	E129H	a
RDKY7097	MLH1	H718Y	H733Y	a
RDKY7098	MLH1	I219L	V216L	a
RDKY7099	MLH1	S406N	S415N	a
RDKY7105	MSH2	G322D	G317D	a
RDKY7106	MSH2	N127S	N123S	a
RDKY7108	MSH6	S503C	S406C	a
RDKY4488	MSH6	L396V	L301V	a
RDKY7109	MSH6	K1358DfsX1	Asp1239X	a
RDKY7111	PMS1	T485K	T505K	a
RDKY7112	PMS1	N775S	Q808S	a

Plasmid alleles
Plasmid no.	Gene	Human allele	S. cerevisiae allele	Source
Mutations
pAG207	MSH2	C199R	C195R	a; 17
pAG80	MSH2	D167H	D163H	a; 17
pAG25	MSH2		G122S	c; 17
pAG204	MSH2	I145M	I141M	a; 17
pAG203	MSH2	N127S	N123S	a; 17
pAG413	MSH2	Q61P	Q61P	a; 17
pAG401	MSH2	T44M	T44M	a; 17
pAG414	MSH2	Y98C	Y104C	a; 17
pRDK1523	MSH2	T33P	T33P	a
pRDK1524	MSH2	V34E	I34E	a
pRDK1525	MSH2	D49V	D49V	a
pRDK1526	MSH2	L93P	L99P	a
pRDK1527	MSH2	R96H	L102H	a
pRDK1528	MSH2	Y103C	Y109C	a
pRDK1529	MSH2	V163D	V159D	a
pRDK1530	MSH2	L187P	L183P	a

a, inSIGHT database (6) (insight-group.org); b, Available on request; c, E. coli mutation (17).