Fig. 4.
Sensitivity of XMRV to Fv1 and primate TRIM5 proteins. (A) Table indicating the positions of amino acids in capsid that differ between XMRV, N- and B-tropic MLV. (B) FACS profiles of CrFK cells that were transduced with retroviral vectors expressing Fv1n or Fv1b and EYFP before infecting with XMRV and N- or B-tropic MLV carrying the EGFP marker. The percentages of infected Fv1-negative versus Fv1-positive cells are shown above each panel. (C) Ratios of infected restriction factor-positive cells to restriction factor-negative cells. Ratios that are less than 0.3 are taken to represent restriction (shaded black); ratios greater than 0.7 represent absence of restriction (not shaded). Numbers between 0.3 and 0.7 (shaded gray) are taken to represent partial restriction.