Table 2.

Genetic association testing for alcohol dependence: Adjusted odds ratios and confidence intervals for SNPs with P ≤ 1 × 10⁻⁶

					Frequency of test allele				Overall SAGE Sample (n = 3,829)
SNP	Chr	Position (hg18)	Locus and context	Test allele	EA cases	EA controls	AA cases	AA controls	Adjusted OR (95% CI)	P	FDR
rs10893366	11	124,683,613	PKNOX2, intronic	T	0.19	0.15	0.31	0.26	1.39 (1.23–1.58)	1.93E-07	0.178
rs2039617	10	97,749,193	CC2D2B, intronic	T	0.06	0.10	0.33	0.40	0.69 (0.60–0.80)	5.95E-07	0.274
rs9302534	16	17,956,211	Intergenic	C	0.35	0.39	0.73	0.76	0.78 (0.70–0.86)	2.73E-06	0.582
rs1318937	3	15,270,368	SH3BP5, intronic	G	0.15	0.11	0.51	0.45	1.35 (1.19–1.52)	3.54E-06	0.582
rs2700648	3	100,590,373	Intergenic	A	0.29	0.24	0.45	0.40	1.29 (1.16–1.44)	3.99E-06	0.582
rs10803574	2	139,427,333	Intergenic	A	0.45	0.40	0.17	0.14	1.28 (1.15–1.43)	4.41E-06	0.582
rs6483362	11	88,052,099	GRM5, intronic	A	0.09	0.07	0.30	0.24	1.42 (1.22–1.66)	4.53E-06	0.582
rs2722650	19	49,593,366	ZNF285A, intronic	A	0.14	0.17	0.57	0.63	0.76 (0.67–0.86)	7.14E-06	0.582
rs10893365	11	124,681,647	PKNOX2, intronic	C	0.19	0.15	0.44	0.41	1.31 (1.17–1.48)	7.20E-06	0.582
rs1386449	11	19,444,659	Intergenic	T	0.00	0.00	0.14	0.07	1.98 (1.47–2.67)	7.29E-06	0.582
rs750338	11	124,677,803	PKNOX2, intronic	C	0.26	0.20	0.47	0.45	1.28 (1.15–1.43)	7.61E-06	0.582
rs1505846	2	139,494,752	Intergenic	A	0.45	0.40	0.17	0.14	1.28 (1.15–1.42)	8.01E-06	0.582
rs9636231	2	139,388,425	Intergenic	A	0.32	0.26	0.14	0.12	1.30 (1.16–1.46)	9.13E-06	0.582
rs1363605	5	172,949,693	Intergenic	A	0.15	0.17	0.36	0.44	0.76 (0.68–0.86)	9.62E-06	0.582
rs10224675	7	143,923,695	TPK1, intronic	G	0.00	0.00	0.06	0.10	0.46 (0.33–0.65)	9.75E-06	0.582

AA, African-American; Chr, chromosome; EA, European-American; FDR, false discovery rate.