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pKa values for the designed retroaldolases obtained from pH-rate profiles and estimated catalytic contribution calculated with a Brønsted value of +0.54
| Retroaldolase | pKa | Estimated catalytic contribution |
| RA34 | > 7 | ≤ 14-fold |
| RA45 | 7.5 | 14-fold |
| RA60 | 7.2 | 13-fold |
| RA61 | 6.8 | 10-fold |
