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. Author manuscript; available in PMC: 2010 Mar 19.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2009 Jun 24;50(12):5522–5528. doi: 10.1167/iovs.09-3804

Figure 5.

Figure 5

Histopathology of liver metastases arising from CXCR4 siRNA-transfected OCM3 uveal melanoma cells. OCM3 uveal melanoma cells were transfected with either CXCR4 siRNA or control siRNA. OCM3 uveal melanoma cells (2 × 105) were injected into the spleen capsules of NOD-SCID mice. Mice underwent necropsy 35 days later, and livers were processed for conventional hematoxylin and eosin staining. (A, D) Untreated. (B, E) siRNA control-treated OCM3 uveal melanoma cells. (C, F) CXCR4 siRNA-treated OCM3 melanoma cells. Arrow: metastatic tumor nodules. (A–C) Low power and (D–F) high-power photographs of A–C, respectively.