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. 2010 Feb 17;30(7):2636–2649. doi: 10.1523/JNEUROSCI.4456-09.2010

Figure 6.

Figure 6.

Inhibition of CaN–NFAT interaction by VIVIT prevents TgCM-induced morphological abnormalities. Dendritic dystrophies (A), dendritic attenuation (B, C), and spine loss (D) in wild-type cultured neurons growing in TgCM are significantly prevented by VIVIT (catalog #480401; Calbiochem). *p < 0.05 in C (TgCM with VIVIT vs TgCM with DMSO). Data are mean ± SD from three independent experiments in triplicate. E–H, Inhibition of CaN–NFAT interaction by VIVIT prevents APP overexpression-induced morphological abnormalities. In Tg cultures at 21 DIV, dendritic dystrophies (E), dendritic attenuation (F, G), and spine loss (H) are prevented by VIVIT. *p < 0.05 in G (Tg with VIVIT vs Tg with DMSO). Data are mean ± SD from three independent experiments in triplicate.