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. Author manuscript; available in PMC: 2011 Feb 25.
Published in final edited form as: Neuron. 2010 Feb 25;65(4):445–459. doi: 10.1016/j.neuron.2010.01.016

Figure 1. mGluR-LTD in health and disease.

Figure 1

Experimental evidence suggest the involvement of mGluR-LTD in goal directed learning, and cerebellar circuit adjustment during motor learning. Excessive mGluR-LTD has been linked to Alzheimer disease and Fragile X syndrome, while a loss of mGluR-LTD in the striatum may contribute to Parkinson’s symptoms. Finally, reduced mGluR-LTD in the midbrain has been suggested to confer a vulnerability of drug addiction. The group 1 mGluRs, mGluR1 and mGluR5 are differentially expressed in most brain regions, and co-expressed in some, based on (Ferraguti and Shigemoto, 2006). mGluR1 expression is indicated by the diagonal lines and mGluR5 expression pattern is indicated by the dotted stipple. Gray stipple indicates a lower level of expression.