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The presence of both CD4+ and CD8+ T cells is necessary for normal IL-17 production in response to K. pneumoniae. Ab depletion of CD4+ or CD8+ T cells reduces the IL-17 content in BAL fluid from C57/BL6 mice 24 h after i.t. challenge. Combined neutralization results in significant abrogation of detectable IL-17 (n = 6 per group; *, p < 0.05 compared with Ab-untreated animals).
