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Effect of chloramphenicol on the lethal action of fluoroquinolones. Cultures of wild-type E. coli strain DM4100 were treated with PD161148 (C8-OMe, •), PD160793 (C8-H, ▴), and ciprofloxacin (▪) for 1 hr in the presence of 20 μg/ml chloramphenicol. Aliquots were then removed, diluted, and plated on drug-free agar for determination of viable cells. Similar results were obtained in two replicate experiments.
