Table 1.

Acquisition of spontaneous fluoroquinoloneresistant mutants

Line	Fluoroquinolone	Conc., μg/ml	Resistant mutants recovered
			Exp. 1	Exp. 2	Exp. 3	Total
1	C8-H (PD160793)	0.34*	300	444	563	1,307
2	C8-OMe (PD161148)	1*	0	0	0	0
3	C8-H (ciprofloxacin)	0.1*	287	175	770	1,232
4	C8-OMe (PD135042)	0.23*	0	0	0	0
5	C8-H (ciprofloxacin)	0.14	159	593	1,032	1,784
6	C8-OMe (PD135042)	0.14	0	0	0	0

^*Concentrations used represented 10 times the MIC for wild-type E. coli (strain DM4100).