FIG. 1.

Chaetocin inhibits thioredoxin reductase activity. (A) Chemical structure of chaetocin. (B) Thioredoxin reductase activity (assessed by following DTNB reduction) is inhibited by chaetocin in a dose-dependent fashion. (C) Time versus absorbance data showing inhibition of DTNB reduction by chaetocin at various concentrations and times. Data shown in (B) represent the means of triplicate data points, error bars, one standard deviation, *p < 0.05, **p < 0.01, and ***p < 0.001 different from diluent control values; while data shown in (c) are representative of a minimum of three separate experiments.