TABLE 2.
Biochemical tissues parameters after 7 weeks treatment
| Rats | Lean (fa/+) | fa/fa |
|||
|---|---|---|---|---|---|
| Treatment | Naive | Naive | 6E-CDCA | Rosiglitazone | Rosiglitazone +6E-CDCA |
| Liver FFA (nmol/mg protein) | 739.8 ± 98.7 | 1,124.0 ± 192.5# | 430.0 ± 42.2* | 907.0 ± 274.0* | 810.0 ± 125.0* |
| Liver cholesterol (µg/mg) | 0.7 ± 0.1 | 1.7 ± 0.2# | 0.3 ± 0.1* | 1.5 ± 0.1 | 1.1 ± 0,1* |
| Liver glycogen (µg/mg protein) | 148.1 ± 16.0 | 6,054.0 ± 1362.0# | 342.8 ± 55.0* | 2217.0 ± 574.0* | 1,376.0 ± 368.0* |
| Muscle triglyceride (µg/mg protein) | 1.8 ± 0.7 | 8.5 ± 0.9# | 2.7 ± 0.5* | 7.5 ± 1.5 | 4.8 ± 1.9 |
| Muscle FFA (nmol/mg protein) | 151.8 ± 26.6 | 608.0 ± 66.8# | 204.0 ± 40.9* | 349.0 ± 105.0 | 282.0 ± 31.7* |
| Muscle cholesterol (µg/mg protein) | 0.4 ± 0.1 | 2.1 ± 0.1# | 0.2 ± 0.1* | 1.3 ± 0.3* | 1.3 ± 0.5* |
Data are mean ± SE (n = 12).
# P < 0.05, fa/fa versus lean.
*P < 0.05, treatment versus naive fa/fa.