TABLE 2.
Associations between noncholesterol sterols and LDL-C change
| Simvastatin 80 mg (N = 289) |
Ezetimibe/Simvastatin 10/80 mg (N = 302) |
|||
|---|---|---|---|---|
| Baseline Noncholesterol Sterols | β | P | β | P |
| Campesterol (mg/dl) | −0.072 | 0.166 | 0.009 | 0.825 |
| Sitosterol (mg/dl) | −0.020 | 0.705 | −0.010 | 0.806 |
| Lathosterol (mg/dl) | −0.001 | 0.981 | 0.057 | 0.148 |
| Campesterol/TC (μg/mg) | −0.051 | 0.287 | 0.020 | 0.587 |
| Sitosterol/TC (μg/mg) | 0.008 | 0.871 | <0.001 | 0.992 |
| Lathosterol/TC (μg/mg) | 0.005 | 0.927 | 0.053 | 0.154 |
| Change in Sterols | Simvastatin 80 mg (N = 289) | Ezetimibe/Simvastatin 10/80 mg (N = 302) | ||
| Δ Campesterol 2y (mg/dl) | 0.235 | <0.001 | 0.081 | 0.047 |
| Δ Sitosterol 2y (mg/dl) | 0.206 | <0.001 | 0.125 | 0.003 |
| Δ Lathosterol 2y (mg/dl) | 0.232 | <0.001 | 0.157 | <0.001 |
| Δ Campesterol/TC 2y (μg/ml) | −0.180 | <0.001 | −0.013 | 0.736 |
| Δ Sitosterol/TC 2y (μg/ml) | −0.193 | <0.001 | −0.021 | 0.570 |
| Δ Lathosterol/TC 2y (μg/ml) | 0.135 | 0.001 | 0.083 | 0.026 |
Data were analyzed in a multiple regression model with LDL-C change from baseline as dependent variable and the noncholesterol sterol and baseline LDL-C as independent variables. In addition, associations between change in absolute noncholesterol sterol levels and LDL-C change were analyzed. In this model, LDL change from baseline served as dependent variable and change in the noncholesterol sterol and baseline LDL-C as independent variables. β represents the standardized β coefficient.