Fig. 4.

Effects of GW3965 LXR agonist on macrophage-to-feces RCT. Hamsters on a chow + 0.3% cholesterol diet were orally treated twice daily for 7 days with vehicle (0.5% hydroxypropyl methylcellulose) or GW3965 (30 mg/kg) and then injected with ³H-cholesterol labeled macrophages. Animals were treated with vehicle or GW3965 during the 72 h experiment. Time course of ³H-cholesterol distribution in plasma of hamsters of each group was established (A) after injection of radiolabeled macrophages. Liver (B) and fecal (C) ³H-tracer recovery in hamsters of vehicle group (solid bars) and GW3965 group (gray bars) were also monitored. Data are expressed as percent of dpm injected ± SEM (n = 6 per group, * P < 0.05; ** P < 0.01; *** P < 0.001 vs. vehicle).