Fig. 5.

Effects of GW3965 LXR agonist on HDL-cholesteryl esters kinetics and HDL-derived fecal cholesterol excretion. Hamsters on a chow + 0.3% cholesterol diet were orally treated twice daily for 8 days with vehicle (0.5% hydroxypropyl methylcellulose) or GW3965 (30 mg/kg) and then injected with ³H-cholesteryl oleate labeled HDL. Animals were treated with vehicle or GW3965 during the 48 h experiment. After injection of radiolabeled HDL, plasma decay curves (A) of vehicle- (solid plots) and GW3965-treated hamsters (gray plots) were analyzed and fitted curves (dashed line) and FCR were calculated by SAAMII software. Fecal ³H tracer recovery (B) were detected in hamsters treated with vehicle (solid bars) or GW3965 LXR agonist (gray bars). Values are means ± SEM (n = 6 per group, ** P < 0.01 vs. vehicle).