Table 3.
Adjusted Longitudinal Comparisons of Mean Cognitive Function Scores at Study Follow-up in 1999–2002 by Baseline Urine ACR Category in 1992–1996,a Rancho Bernardo, California
| Women (n = 461) |
Men (n = 298) |
|||||
| ACR <30 (n = 406) | ACR ≥30 (n = 55) | P Value | ACR <30 (n = 263) | ACR ≥30 (n = 35) | P Value | |
| MMSE | ||||||
| Unadjusted | 27.6 | 27.8 | 0.54 | 27.7 | 26.4 | <0.01 |
| Age adjusted | 27.6 | 28.0 | 0.18 | 27.6 | 26.8 | <0.05 |
| All adjustedb | 27.7 | 28.0 | 0.36 | 27.7 | 26.6 | 0.02 |
| Trails B | ||||||
| Unadjusted | 129.5 | 150.6 | 0.03 | 114.8 | 152.5 | <0.01 |
| Age adjusted | 130.8 | 141.7 | 0.21 | 117.1 | 133.5 | 0.12 |
| All adjustedb | 129.1 | 133.4 | 0.62 | 112.5 | 132.9 | <0.05 |
| Category fluency | ||||||
| Unadjusted | 16.1 | 16.5 | 0.62 | 17.8 | 16.0 | <0.05 |
| Age adjusted | 16.1 | 16.8 | 0.24 | 17.7 | 16.8 | 0.31 |
| All adjustedb | 16.2 | 16.6 | 0.57 | 18.0 | 15.6 | 0.01 |
Abbreviations: ACR, albumin/creatinine ratio; MMSE, Mini-Mental State Examination; Trails B, Trail-Making Test B.
a
Results of analysis of covariance.
b
Adjusted for baseline age, systolic blood pressure, hemoglobin A1C, education (some college), strenuous exercise 3 or more times per week, alcoholic beverage consumption 3 or more times per week, baseline score on cognitive function test, current estrogen use (women only), estimated glomerular filtration rate, Beck Depression Inventory score, antihypertensive medication use, and lipid-lowering medication use.