Table 3.

Status Two and Five Years Post-Surgery

	Plasmid %		Tumor %		Margins by Light Microscopy		Type of Mutation
					All Negative	Any Positive	Conservative	Disruptive
	<0.15	≥0.15	<0.5	≥0.5
Patients	54	41	60	35	85	10	61	34
Local Failure-free Survival Events	13	15	13	15	25	3	15	13
2-Yr Local Failure-free Survival	81.7%	65.3%	83.5%	58.9%	75.4%	70.0%	78.0%	68.7%
95% CI	71.5 – 93.3%	51.7 – 82.6%	74.2 – 94.0%	44.0 – 79.0%	66.3 – 85.7%	46.7 – 100.0%	67.7 – 89.9%	54.3 – 86.9%
5-Yr Local Failure-free Survival	68.4%	65.3%	70.5%	58.9%	66.3%	70.0%	68.2%	64.1%
95% CI	54.8 – 85.4%	51.7 – 82.6%	57.4 – 86.7%	44.9 – 79.0%	55.3 – 79.4%	46.7 – 100.0%	55.3 – 84.1%	48.9 – 84.1%
Logrank p	0.13		0.02		0.80		0.18
Deaths from Head & Neck Cancer	17	16	21	12	29	4	17	16
2-Yr Cancer-specific Survival	75.7%	62.3%	74.8%	60.9%	69.4%	77.8%	77.1%	58.6%
95% CI	64.5 – 88.7%	47.8 – 81.0%	64.2 – 87.2%	45.1 – 82.3%	59.6 – 80.7%	54.9 – 100.0%	66.4 – 89.5%	43.6 – 78.7%
5-Yr Cancer-specific Survival	63.8%	51.7%	59.7%	56.9%	60.0%	51.9%	66.1%	48.3%
95% CI	50.5 – 80.7%	36.8 – 72.4%	46.9 – 76.0%	40.9 – 79.1%	49.2 – 73.3%	26.7 – 100.0%	53.3 – 81.9%	33.4 – 69.7%
Logrank p	0.28		0.72		0.88		0.69
Deaths from Any Cause	32	28	36	24	54	6	36	24
2-Yr Overall Survival	62.6%	47.2%	62.8%	44.2%	55.5%	60.0%	59.4%	50.0%
95% CI	50.8 – 77.0%	33.9 – 65.6%	51.6 – 76.4%	30.3 – 64.4%	45.7 – 67.3%	36.2 – 99.5%	48.1 – 73.4%	35.7 – 70.0%
5-Yr Overall Survival	40.1%	34.1%	38.6%	35.3%	37.6%	40.0%	39.9%	34.6%
95% CI	28.2 – 56.9%	22.0 – 52.7%	27.3 – 54.4%	22.4 – 55.7%	28.2 – 50.2%	18.7 – 85.5%	28.8 – 55.3%	21.6 – 55.3%
Logrank p	0.25		0.31		0.69		0.36