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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Nat Immunol. 2010 Feb 28;11(4):321–327. doi: 10.1038/ni.1849

Figure 4. Ly49C/I-mediated inhibition requires functional SHP-1.

Figure 4

IFN-γ and degranulation by mixed bone marrow chimeric (a) Ly49H+ wild-type NK cells and (b) Ly49H+ SHP-1Me-v NK cells stimulated with RMA-S-m157 or RMA-m157 targets in the presence or absence of blocking antibody to H-2Kb. Data are representative of three experiments with 3–4 mice per experiment. (c) Ly49C/Iexpression was analyzed on mixed bone marrow chimeric Ly49H+ wild-type and SHP-1Me-v NK cells prior to infection and 5 days after MCMV infection. Data are representative of three experiments with 3–4 mice per group. (d) CFSE dilution by Ly49C/I+ (gray fill) and Ly49C/I− (black line) mixed bone marrow chimeric Ly49H+ wild-type and SHP-1Me-v NK cells 5 days after MCMV infection. Data are representative of three experiments with 2–3 animals each.