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Main relationship between Toll-like receptor (TLR)2 and 4, their adaptors, protein kinases, which are linked to them and downstream signaling effects[26]. LPS: Lipopolysaccharide; LBP: LPS binding protein; CD14: Cluster of differentiation 14; ERK: Extracellular signal-regulated kinase; JNK: Jun N-terminal kinase; NF-κB: Nuclear factor κB; AP-1: Activator protein 1; TNF: Tumor necrosis factor.
