Table 4.
Hazard Ratios for the Relationship Between Opioid Dosage Level and Fracture
| Opioid dosage level (mg/day) | Number of fractures | Person years | Fracture rate (per person year) | Hazard ratio (95% C.I.)a |
|---|---|---|---|---|
| 0 | 114 | 3,012 | 0.03784 | 1.00 |
| 1–<20 | 152 | 2,684 | 0.05663 | 1.20 (0.92, 1.56) |
| 20–<50 | 33 | 472 | 0.06993 | 1.34 (0.89, 2.01) |
| 50+ | 21 | 211 | 0.09953 | 2.00 (1.24, 3.24) |
| Any Use | 206 | 3,367 | 0.06118 | 1.28 (0.99, 1.64) |
aAdjusted for smoking, depression, substance abuse, dementia, comorbidity, pain site, age, gender, prior fracture, antidepressant use, sedative use, HRT/bisphosphonate use