Table 1.
Potential risk factors for respiratory depression | Potential risk factors for TdP |
---|---|
Advancing age5,32 | Female gender30 |
Medically compromised34 | Electrolyte imbalance27,28 |
Liver or pulmonary pathology8 | Liver or cardiac pathology8 |
Sleep apnea33 | Unexplained syncope or seizures29 |
Polysubstance use19,21 | Other drug and medication use, especially those that impact QTc or inhibit CYP 3A42828,30 |
Opioid-naïve/low tolerance32 | Prolonged QTc24 |
High doses of methadone34 | High doses of methadone27,28 |
Rapid titration of methadone dosing34 |