FIG. 2.

Interactions between BMPs and their antagonists in hypertension. (A) Proposed scheme showing that hemodynamic forces may regulate the expression of both BMP-2/4 and BMP antagonists in vascular cells, which together will determine BMP activity in the vasculature. (B) High pressure may alter the expression of BMP-binding proteins in coronary arteries of aortic banded rats (n = 3). Data are expressed as relative changes in mRNA expression, as compared with vessels of sham-operated rats (n = 5).