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Schematic representation of the most common strategies to deliver drugs from three-dimensional scaffolds in bone TE. Drugs may be adsorbed onto the pore surface of the scaffolds in either their unprotected (a) or their protected (microsphere/matrix) (b) forms. Alternatively, drugs may be entrapped in the scaffold structure in either their unprotected (c) or their protected (microsphere/matrix) (d) forms.
