Figure 2.

Model for activation of NMDA receptors by reelin binding to apoER2. The binding of reelin to apoER2 leads to the formation of a complex in which PSD-95 links the two receptors by binding to the NMDA receptor subunit 2A (NR2A) subunit of the NMDA receptor and the apoER2 tail. Formation of the complex induces recruitment of Src family tyrosine kinases (SFKs), leading to tyrosine phosphorylation of the NR2A subunit of the NMDA receptor. Adapted from Beffert et al. (2005) with the permission of the authors.