Immunoblots of extracts each labeled with anti-PS-1 antibody L3 of mouse 3T3 cultured cells prepared by Method A-Cells (lane 1) and of mouse liver (lane 2), kidney (lane 3), and brain (lane 4), all prepared by Method A-Tissues. The arrowheads indicate the intact monomeric PS-1 species, and the arrow indicates the brain-specific, ≈40-kDa, PS-1-related species.