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Dose response of front-line TB drugs in rats following two-week treatment. log10 CFU counts/left lung lobe plotted against a range of drug regimens. Rifampicin (30, 90 and 270 mg/kg), Isoniazid (10, 30, and 90 mg/kg), Ethambutol (100, 300, and 1000 mg/kg) and Pyrazinamide (300 and 1000 mg/kg) were dosed per oral once daily for two weeks (12 doses). Each bar represents the mean CFU counts from three animals.
