Table 1.

Number of achlorhydric mouse genotypes showing membrane Vd ratios significantly different than WT.

Vd ratio	Number significant	Mouse Model
TV+CAM+BLM/mitochondria	2/6	GHKAα, NHE2GHKAα
CAM /TV	3/6	AE2, GHKAα, NHE2, NHE2AE2
Round vesicles/TV	2/6	GHKAα, NHE2GHKAα
All membranes/mitochondria	5/6	AE2, GHKAα, NHE2, NHE4 NHE2AE2
BLM /mitochondria	6/6	AE2, GHKAα, NHE2, NHE4 NHE2AE2. NHE2GHKAα

Acid secretion was inhibited either by omeprazole treatment or vagotomy. Values for WT parietal cells with acid secretion inhibited were significantly different than untreated WT for Vd of CAM/TV, round vesicles/TV, and basolateral membrane/mitochondria. NHE2−/− inhibited parietal cells were not significantly different than NHE2−/− untreated.