Figure 2.

sFTX effect on α1A, α2δ currents vary depending on the β subunit coexpressed. Dose–response for α1A, α2δ, βIb currents (•), α1A, α2δ, β2a currents (▴), and α1A, α2δ, β3 currents (▾) at the noted sFTX concentrations locally applied through a blunt pipette. Note the difference in sensitivity between the currents produced in cells expressing βIb and the other two subunit combinations (A). α1A, α2δ, βIb whole-cell current using the same protocol as in Fig. 1C, before (control) and after 1 mM sFTX (sFTX 1 mM) (B). The effect of sFTX was observed within ∼1 min, was reversible, and produced a noticeable difference in the τ of inactivation (see text).