Figure 4.
ω-Aga IVA is a specific inhibitor of α1A, α2δ, βIb currents. (A) Comparison of the effect of 100 nM ω-Aga IVA after 8 min of constant local application on α1A, α2δ, βIb (βIb), α1A, α2δ, β2a (β2a) and α1A, α2δ, β3 (β3). (B) α1A, α2δ, β2a currents are inhibited by 500 nM ω-Aga IVA in a reversible fashion, washout (wsh) is increased on strong prepulse depolarizations (wsh++) (see text). (C) ω-Aga IVA effect on α1A, α2δ, βIb currents before (control) and after 100 nM Aga IVA, application (Aga IVA) and on toxin withdrawal and high depolarization protocol (wsh++).