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Extended haplotype homozygosity (EHH) versus physical distance for 3 core SNPs (two nonsynonymous and one regulatory) in PCSK9: SNP rs2479409 is in the regulatory region, and SNPs rs562556 (I474V) and rs505151 (E670G) are in the coding regions. In each plot, black represents African-Americans; red, European-Americans. The solid and broken lines indicate the ancestral and derived allele, respectively. SNP rs505151 is not a common SNP in European-Americans.
