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Orientation of ZAP-70 influences its kinase function. A CID strategy was used to explore the influence of ZAP-70 orientation on function of this kinase. The chemical structures of three dimerizer compounds are shown, FK1012, FK1012H2, and FK1012Z. These dimers present REs in three distinct relative orientations. The relative abilities of these compounds to induce ZAP-70 activity were similar.
