Figure 1.
Whisker conditioning induces a large increase in the density of symmetrical synapses (ANOVA, p < 0.001), whereas pseudoconditioning and whisker stimulation alone increased the density of asymmetrical synapses (ANOVA, p < 0.001 and p < 0.05, respectively). A, An electron micrograph taken from a B2 barrel hollow showing an asymmetrical synapse (black arrow) and a symmetrical synapse (white arrow), both located on the same dendritic spine (S). B, Total density of synapses for individual animals belonging to the following groups: control; CS–UCS, conditioned; CS, stimulated only; Pseudo, pseudoconditioned. C, Density of asymmetrical synapses for individual animals belonging to groups of treatment as in B. D, Density of symmetrical synapses for individual animals belonging to groups of treatment as in B. Scale bar, 0.5 μm. Horizontal line through the points in B–D indicates the mean.