Table 1.

Kinetic parameters following administration of rHDL in mice

	apoA-I FCR pool/h	PC FCR pool/h	PC trans. mg/kg/h	FC FCR pool/h	FC trans. AUC (mg/kg)*h	Rapid FC trans. AUC (mg/kg)*h
C57BL/6 (n=8)	0.09 ± 0.01	0.67 ± 0.19	26.16 ± 5.89	0.95 ± 0.22	182.28 ± 50.86	23.11 ± 5.47
SRBI-WT (n=4)	0.04 ± 0.03	0.50 ± 0.07	30.39 ± 4.88	1.01 ± 0.06	241.00 ± 49.64	27.96 ± 9.99
SRBI-KO (n=3)	0.04 ± 0.01	0.37 ± 0.20	33.51 ± 19.60	0.18 ± 0.01	274.59 ± 15.25	1.01 ± 1.75
p value	0.88	0.27	0.76	<0.001	0.33	0.006
ABCA1-WT (n=4)	0.07 ± 0.01	0.51 ± 0.14	25.96 ± 6.89	1.25 ± 0.14	267.35 ± 39.93	53.86 ± 4.19
ABCA1-KO (n=4)	0.18 ± 0.04	0.54 ± 0.08	14.94 ± 2.96	1.36 ± 0.16	230.36 ± 35.36	63.95 ± 12.72
p value	0.002	0.73	0.03	0.36	0.21	0.18
ABCG1-WT (n=5)	0.08 ± 0.01	0.40 ± 0.04	16.05 ± 5.31	1.09 ± 0.12	311.74 ± 28.43	17.73 ± 10.06
ABCG1-KO (n=5)	0.07 ± 0.01	0.48 ± 0.04	21.21 ± 2.42	1.16 ± 0.15	311.02 ± 36.73	21.83 ± 2.75
p value	0.13	0.01	0.08	0.45	0.97	0.41

ApoA-I, human apolipoprotein A-I; FCR, fractional catabolic rate; PC, phosphatidylcholine; trans, transport; FC, free cholesterol; AUC, area under the curve; WT, control wild type mice; KO, knockout mice.

Values for C57BL/6 mice are shown for comparison.

p values refer to comparison between the wild type control mice (WT) and the knockout (KO) mice.