Table 1.
Target | Drug | Animal Model | Results | Reference |
---|---|---|---|---|
Spleen Tyrosine Kinase | R788/R406 | Murine CIA† | ↓ Arthritis | [68] |
↓ Cytokines | ||||
MEK | PD184352 | Murine CIA | ↓ Arthritis | [82] |
↓ Proteoglycan degradation | ||||
ERK | FR180294 | Murine CIA | ↓ T cell activation | [83] |
miR-15a | miR-15a | Murine Autoantibody‡ | ↑ Apoptosis | [85] |
↓ bcl-2 | ||||
↑ caspase-3 | ||||
TRAIL | rhTRAIL* | Rabbit IL-1β-transfected fibroblasts** | ↑ Apoptosis | [86] |
↓ Lymphocyte infiltration | ||||
Proteasome | Bortezomib | Murine CIA | ↓ Arthritis | [87] |
↓ TNF-α,IL-1β, IL-6,iNOS, COX-2 | ||||
↓ MMP-3 |
†Type II Collagen-Induced Arthritis
‡FAM-atelocollagen + miR-15a
*Recombinant human TRAIL
**IL-1β-transfected human fibroblasts engrafted into rabbit synovial joint.