Figure 3.

Effects of IGF-I (A), des(1–3) IGF-I (B), and IGF-II (C) on evoked ACh release from hippocampal slices. Slices were depolarized with 25 mM K⁺ buffer in the presence or absence of various concentrations of IGF-I, des(1–3) IGF-I, and IGF-II. Evoked release was significantly inhibited by IGF-I (A) and des(1–3) IGF-I (B) while potentiated by IGF-II (C). Results are expressed as the mean ± SEM of three experiments each performed quintuplicate for each concentration of peptide tested. cont, Control. *P < 0.05.