FIGURE 2.

External high potassium increases KCNQ2/Q3 currents. A, external K⁺ increased from 1 (ND96) to 10 mm (ND96–10K) did not affect the depolarization-induced potentiation of KCNQ2/Q3 currents. Black and gray lines indicate the current traces before and after a 15-min depolarization, respectively. B, summary data for A. C, incubation with high external K⁺ solution (ND96K) increased KCNQ2/Q3 currents. D, comparison of KCNQ2/Q3 current potentiation by depolarization (0 mV, 15 min) and high K⁺ solution incubation (15 min). E, G-V curves for KCNQ2/Q3 channels before and after a15-min incubation with high K⁺ solution incubation. The data were fitted with the Boltzmann function. **, p < 0.01.