FIGURE 5.

Hypertonic stress reduces the depolarization-induced potentiation of KCNQ2/Q3 currents. A, oocytes were incubated in either normal (NT) or hypertonic solution (HT, ND96 plus 96 mm NaCl) for 10 min, and then were depolarized to 0 mV for 10 min. B, summary data for: control (current amplitudes at the beginning of 10 min depolarization at 0 mV) after 10 min of incubation in either normal (NT) or hypertonic solution (HT), increased currents by 10 min depolarization at 0 mV (0 mV), and total increased currents by 10 min of HT incubation and 10 min of 0 mV depolarization (control + 0 mV) compared with NT control. **, p < 0.01.