TABLE 1.
Genes affected by contact normalization of Src transformed cells
Symbol | Probe sets | Fold change |
Gene name | |
---|---|---|---|---|
Srca | CNb | |||
Genes increased by Src and decreased during contact normalization | ||||
1700012B09Rikc | 1428984_a_at | 115 | −3.4 | RIKEN cDNA 1700012B09 gene |
Pdpnc | 1419309_at | 93 | −4.7 | Podoplanin |
Tmem163c | 1428077_at | 58 | −5.5 | Transmembrane protein 163 |
Smoc2 | 1415935_at | 47 | −6.6 | SPARC-related modular calcium binding 2 |
Pstpip2 | 1421410_a_at | 41 | −4.5 | Proline-serine-threonine phosphatase-interacting protein 2 |
Mal | 1417275_at | 30 | −5.6 | Myelin and lymphocyte protein |
Lepr | 1425644_at | 28 | −4.7 | Leptin receptor |
Elavl2 | 1421883_at | 26 | −9.9 | Embryonic lethal abnormal vision-like 2 |
Igsf11 | 1460607_at | 26 | −5.0 | Immunoglobulin superfamily, member 11 |
Mafb | 1451715_at | 14 | −6.7 | v-Maf protein B |
LOC677224c | 1435703_at | 13 | −3.5 | Similar to RIKEN cDNA 2810457I06 |
4930408O21Rikc | 1431741_a_at | 8.8 | −4.8 | RIKEN cDNA 4930408O21 gene |
Elmod1 | 1457223_at | 8.3 | −5.0 | ELMO domain-containing 1 |
Atp13a4 | 1438707_at | 7.8 | −4.7 | ATPase type 13A4 |
Kdr | 1449379_at | 6.6 | −3.7 | Kinase insert domain protein receptor |
C9 | 1422815_at | 5.4 | −4.9 | Complement component 9 |
Genes decreased by Src and increased during contact normalization | ||||
Fgf7 | 1438405_at | −130 | 46 | Fibroblast growth factor 7 |
D10Bwg1379e | 1435050_at | −95 | 13 | DNA segment Chr 10 Brigham and Women's Genetics 1379 expressed |
Sox11 | 1431225_at | −93 | 16 | SRY box-containing gene 11 |
Ccl20 | 1422029_at | −91 | 12 | Chemokine (C-C motif) ligand 20 |
Vcam1d | 1448162_at | −78 | 22 | Vascular cell adhesion molecule 1 |
1415989_at | −56 | 16 | ||
1451314_a_at | −55 | 12 | ||
Sema3e | 1427673_a_at | −71 | 8.3 | Semaphorin 3E |
Sdprd | 1416779_at | −47 | 13 | Serum deprivation response |
1416778_at | −39 | 11 | ||
Epha4 | 1429021_at | −44 | 8.3 | Eph receptor A4 |
Ntn1 | 1454974_at | −42 | 17 | Netrin 1 |
Cabc1 | 1417066_at | −32 | 5.0 | Chaperone, ABC1 activity of bc1 complex like (Schizosaccharomyces pombe) |
Spry1 | 1415874_at | −26 | 4.5 | Sprouty homolog 1 (Drosophila) |
Loxl1 | 1451978_at | −25 | 9.9 | Lysyl oxidase-like 1 |
1810008K04Rikc | 1441254_at | −19 | 9.0 | RIKEN cDNA 1810008K04 gene |
Pdgfrb | 1436970_a_at | −18 | 3.9 | Platelet-derived growth factor receptor β polypeptide |
D4Bwg0951ec | 1428384_at | −17 | 4.2 | DNA segment Chr 4 Brigham and Women's Genetics 0951 expressed |
Fhl1c,d | 1417872_at | −16 | 11 | Four and a half LIM domains 1 |
Gpr126 | 1437408_at | −16 | 5.7 | G protein-coupled receptor 126 |
1437409_s_at | −13 | 5.7 | ||
Egfr | 1435888_at | −16 | 5.2 | Epidermal growth factor receptor |
Itih2 | 1417618_at | −12 | 7.3 | Inter-α-trypsin inhibitor heavy chain 2 |
Epb4.1l3 | 1419062_at | −12 | 5.6 | Erythrocyte protein band 4.1-like 3 |
Il1rl1 | 1425145_at | −9.7 | 8.3 | Interleukin 1 receptor-like 1 |
Wnt5a | 1448818_at | −9.1 | 4.6 | Wingless-related MMTV integration site 5A |
Tmem56 | 1434553_at | −8.2 | 4.4 | Transmembrane protein 56 |
a Expression in Src-transformed cells divided by expression in nontransformed cells.
b Expression in transformed cells divided by expression in transformed cells undergoing contact normalization.
c Effects confirmed by RT-PCR (see Fig. 1).
d Genes previously shown to be induced by contact normalization.