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. 2010 Feb 1;285(13):9649–9656. doi: 10.1074/jbc.M109.047696

TABLE 1.

Genes affected by contact normalization of Src transformed cells

Symbol Probe sets Fold change
Gene name
Srca CNb
Genes increased by Src and decreased during contact normalization
    1700012B09Rikc 1428984_a_at 115 −3.4 RIKEN cDNA 1700012B09 gene
    Pdpnc 1419309_at 93 −4.7 Podoplanin
    Tmem163c 1428077_at 58 −5.5 Transmembrane protein 163
    Smoc2 1415935_at 47 −6.6 SPARC-related modular calcium binding 2
    Pstpip2 1421410_a_at 41 −4.5 Proline-serine-threonine phosphatase-interacting protein 2
    Mal 1417275_at 30 −5.6 Myelin and lymphocyte protein
    Lepr 1425644_at 28 −4.7 Leptin receptor
    Elavl2 1421883_at 26 −9.9 Embryonic lethal abnormal vision-like 2
    Igsf11 1460607_at 26 −5.0 Immunoglobulin superfamily, member 11
    Mafb 1451715_at 14 −6.7 v-Maf protein B
    LOC677224c 1435703_at 13 −3.5 Similar to RIKEN cDNA 2810457I06
    4930408O21Rikc 1431741_a_at 8.8 −4.8 RIKEN cDNA 4930408O21 gene
    Elmod1 1457223_at 8.3 −5.0 ELMO domain-containing 1
    Atp13a4 1438707_at 7.8 −4.7 ATPase type 13A4
    Kdr 1449379_at 6.6 −3.7 Kinase insert domain protein receptor
    C9 1422815_at 5.4 −4.9 Complement component 9

Genes decreased by Src and increased during contact normalization
    Fgf7 1438405_at −130 46 Fibroblast growth factor 7
    D10Bwg1379e 1435050_at −95 13 DNA segment Chr 10 Brigham and Women's Genetics 1379 expressed
    Sox11 1431225_at −93 16 SRY box-containing gene 11
    Ccl20 1422029_at −91 12 Chemokine (C-C motif) ligand 20
    Vcam1d 1448162_at −78 22 Vascular cell adhesion molecule 1
1415989_at −56 16
1451314_a_at −55 12
    Sema3e 1427673_a_at −71 8.3 Semaphorin 3E
    Sdprd 1416779_at −47 13 Serum deprivation response
1416778_at −39 11
    Epha4 1429021_at −44 8.3 Eph receptor A4
    Ntn1 1454974_at −42 17 Netrin 1
    Cabc1 1417066_at −32 5.0 Chaperone, ABC1 activity of bc1 complex like (Schizosaccharomyces pombe)
    Spry1 1415874_at −26 4.5 Sprouty homolog 1 (Drosophila)
    Loxl1 1451978_at −25 9.9 Lysyl oxidase-like 1
    1810008K04Rikc 1441254_at −19 9.0 RIKEN cDNA 1810008K04 gene
    Pdgfrb 1436970_a_at −18 3.9 Platelet-derived growth factor receptor β polypeptide
    D4Bwg0951ec 1428384_at −17 4.2 DNA segment Chr 4 Brigham and Women's Genetics 0951 expressed
    Fhl1c,d 1417872_at −16 11 Four and a half LIM domains 1
    Gpr126 1437408_at −16 5.7 G protein-coupled receptor 126
1437409_s_at −13 5.7
    Egfr 1435888_at −16 5.2 Epidermal growth factor receptor
    Itih2 1417618_at −12 7.3 Inter-α-trypsin inhibitor heavy chain 2
    Epb4.1l3 1419062_at −12 5.6 Erythrocyte protein band 4.1-like 3
    Il1rl1 1425145_at −9.7 8.3 Interleukin 1 receptor-like 1
    Wnt5a 1448818_at −9.1 4.6 Wingless-related MMTV integration site 5A
    Tmem56 1434553_at −8.2 4.4 Transmembrane protein 56

a Expression in Src-transformed cells divided by expression in nontransformed cells.

b Expression in transformed cells divided by expression in transformed cells undergoing contact normalization.

c Effects confirmed by RT-PCR (see Fig. 1).

d Genes previously shown to be induced by contact normalization.